The epithelial-mesenchymal transition EMT is considered fundamental for overcoming the in situ stage of melanoma and its proliferation beyond the basal membrane.
We also presented some partial personal unpublished results. It is well established by now that progression of melanoma depends on ECM remodeling, TIMPs family being one of the most important regulators of this process. We consider some correlations are needed to be done also with other consecrated histological as Clark level, Breslow indexes, presence of ulceration, mitotic index, intratumor inflammatory infiltrate, etc. In this light, we consider that our study could further clarify the significance of TIMPs expression in this specific type neuroendocrine cancer day 2020 melanoma.
Protective and therapeutic possibility of medical herbs for liver cirrhosis Vesna Stankovic, Vladimir Mihailovic, Slobodanka Mitrovic, Vladimir Jurisic Liver damage is a serious medical problem worldwide and is caused by primary or secondary metabolic, microbiological, toxicological, immunological and circulatory etiological factors.
The objective of this paper is to analyze the hepatoprotective effect of various plants, their biologically active compounds and extracts and the possibility of these compounds to attenuate complex pathophysiology processes during chronic inflammation and the development of liver cirrhosis. This review summarizes several plants whose hepatoprotective effects have been demonstrated and partially describes the mechanisms of inflammation inhibition.
It is known that fibrosis includes an oxidative damage, inflammatory and immune response and star-shaped cells and their activation in hepatocytes. Effects of particular phytocompounds and their anti-inflammatory mechanisms have been studied in several cell lines in vitro, in vivo in different animal models, as well as in some clinical studies. Results suggest that mechanisms include reduction of oxidative stress, papiloma no palato duro of the inflammatory and immune response, as well as the inhibition neuroendocrine cancer day 2020 the activation of hepatic stellate cells HSCsdecreasing extracellular matrix ECM deposition and induction of apoptosis, protection of hepatocytes from apoptosis and creating apoptotic bodies, which are phagocytic and activate HSCs.
Medical herbs are abundant, economical and versatile and thus are potential alternative agents with anti-inflammatory mechanism. They can be a source of bioactive compounds, and with the aim of preventing the formation and progression of fibrosis, they can find wide applications in medical practice. The obtained results should neuroendocrine cancer day 2020 further research in order to identify safe and effective protective and therapeutic resources. This disease is mediated by both humoral and cellular mechanisms and it is the result of combined effects of human leukocyte antigen HLA class II genes and non-HLA genes polymorphisms.
The clinical course of AT is variable and may be characterized by spontaneous remission and by irreversible thyroid insufficiency as the consequence of atrophic and fibrous transformation of the thyroid gland in other cases. In this paper, neuroendocrine cancer day 2020 AT s etiology and immunological mechanism along with its cytological and histopathological features are reviewed in order to increase our understanding about the mechanism involved in pathogenesis of this disease and to open new directions of investigations that will be useful in a better clinical practice.
Inflammatory juvenile compound conjunctival nevi. The aim of this article is tenic de cristal determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva IJCNC in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view.
This article is a clinical pathological study of two cases of IJCNC with particular histopathological characteristics, who were admitted at the 2nd Ophthalmology Clinic, Prof. Both patients were adolescents, a boy year-old and a girl year-old. Both lesions were bulbar juxtalimbal located and grew in size neuroendocrine cancer day 2020 one year.
Seen at slit-lamp biomicroscopy, the first one presented as a non-pigmented lesion, while the second was a pigmented nevus, but their dimensions did not exceed 10 mm in diameter.
From a histopathological point of view, both of them showed a nested junctional growth pattern, along with intra- and subepithelial location, of the nevomelanocytes. Tumoral cells demonstrated different degrees of atypical cytology, but in the second case, it was more obvious. Microscopic examination also revealed epithelial cystic inclusions, and prominent inflammation in the stroma of these two nevi.
One of the cases presented heavy inflammation that took the form of lymphoid follicles and sheets of eosinophils, but the other showed only diffuse inflammation with lymphocytes plasma cells, and eosinophils within its stroma. Conclusions: IJCNC represent a small group of nevi that develop in adolescents and have some particular histopathological features.
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The pathological diagnosis is difficult as the microscopic features are very similar to a neuroendocrine cancer day 2020 melanoma, but a detailed microscopic examination, immunohistochemical stainings and the young age of the patient could help in establishing the benign nature of these lesions.
PV-1 expression could distinguish the subset of caveolae-presenting telocytes that are endothelial progenitors Alexandra Diana Vrapciu, Mugurel Constantin Rusu Telocytes TCs are stromal cells with characteristic long, thin and moniliform prolongations termed telopodes. They were formerly termed interstitial Cajal-like cells.
A characteristic set of markers to identify TCs in light microscopy has not been established until now.
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Telocytes display caveolae and can express caveolin The distinction of this progenitor subset of TCs can be easily made by neuroendocrine cancer day 2020 specific set of ultrastructure markers, as follows.
Caveolae of endothelial cells present stomatal diaphragms SDs. The aim of our study was to assess the immunoexpression of estrogen receptor ER alpha, Ki67, calretinin, and inhibin A in AGCTs, in order to evaluate their value in diagnosis and prognosis of this type of tumor. Immunohistochemical stainings for these markers were performed in 21 cases of AGCTs. Neuroendocrine cancer day 2020 immunopositivity evaluation of calretinin and inhibin A was scored according to the percentage neuroendocrine cancer day 2020 staining intensity and the extent of positive cells, of ER alpha was scored based on the percentage of positive cells, and Ki67 score was recorded as the percentage of positively stained nuclei across the tumor, without taking in consideration the staining intensity.
ER was positive in nine cases, Ki67 was expressed in 12 cases, calretinin showed positive immunoreactivity in 16 cases, and inhibin A was positive in 14 cases. Stromal cells presented also immunopositivity for inhibin A and calretinin in the negative cases.
Our results regarding Neuroendocrine cancer day 2020 expression emphasize the potential utility of this marker in tumor behavior prediction. Inhibin A immunopositivity has an important value in AGCT diagnosis, in association to the other evaluated markers. Additional studies are needed to identify new specific and sensitive markers for AGCT or, at least, of a panel of markers which might contribute to a more accurate characterization of these tumors.
Loss of Neuroendocrine cancer day 2020 expression, nuclear relocation of beta-catenin and high expression of Snail are connected to tumor progression, rapid cell growth and metastasis. The aim of our study was to analyze the immunohistochemical expression of beta-catenin, E-cadherin and Snail, depending on clinico-morphological aspects of the laryngeal squamous cell carcinomas.
Our results revealed variable E-cadherin, beta-catenin and Snail expression, depending on differentiation degree and cum arată enterobioza? stage.
These markers can be helpful in identifying the aggressive laryngeal squamous carcinomas. Integrative clinico-biological, pharmacogenetic, neuroendocrine cancer day 2020, neuroendocrinological and psychological correlations in depressive and anxiety disorders Lavinia Maria Hogea, Laura Alexandra Nussbaum, Daniela Veronica Chiriac, Luminita Stefania Ageu, Nicoleta Ioana Andreescu, Mirela Loredana Grigoras, Roxana Folescu, Ana Cristina Bredicean, Maria Puiu, Elena Cecilia Ildiko Rosca, Mihaela Adriana Simu, Codrina Mihaela Levai We approach the theme of modern treatment strategies, based on clinico-biological, pharmacogenetic, neuroimagistic, neuroendocrinological and psychological integrative correlations in the management of depressive and comorbid anxiety disorders.
We target to evaluate the efficacy of the pharmacogenetic testing and the evolution, functioning of patients in correlation with specific neurobiological, neuroimagistic and neuroendocrinological markers. Our research was conducted between on 80 children and adolescents with depressive and comorbid anxiety disorders - 40 children G1 groupwho benefited in choosing the pharmacotherapy from pharmacogenetic testing and 40 children without testing G2 group.
Also, the patients were evaluated through magnetic resonance MR spectroscopy at baseline and after pharmacotherapy. Our results show statistically significant differences of the clinical scores between the studied groups: for those subjects who benefited of pharmacogenetic testing, the CDRS, the global functioning scores prove a higher clinical improvement, a better compliance and lower PAERS side effects scores and also improvement concerning the MR spectroscopy dosed metabolites values.
Our research was a proof sustaining the use of the pharmaco-genetic testing in clinical practice and the value of investigating relevant neurobiological, neuroimagistic and neuroendocrinological markers for a personalized therapy in depressive disorders. We observed a significant increase in the immunoexpression of collagen I and III in patients with DCM and a significant reduction in the immunoexpression of MMP-1 compared with the control group. The standard histopathological criteria for EC diagnosis lack specificity and not all the cases fulfilling those criteria are considered clinically as EC and treated.
The objective of this study is to refine diagnostic criteria for EC. We have reviewed their clinical and pathological features and tried to define the features differentiating cases considered EC on clinical grounds. Results: We identified EC cases. In 22 cases, pastile de vierme rotunde pentru adulți clinical EC diagnosis was established.
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Immunohistochemical reaction of the glandular epithelium in endometrial hyperplasia compared to endometrial carcinoma Victor Emanuel Stoenescu, Mihaela Niculescu, Liliana Novac, Maria Magdalena Manolea, Paul Ioan Tomescu, Anda Lorena Dijmarescu, Marius Bogdan Novac, Stefania Tudorache, Dominic Gabriel Iliescu The histopathological and immunohistochemical diagnosis of endometrial biopsies is used for estimating the risk of progression in endometrial hyperplastic lesions in carcinoma and for guiding the clinical management.
After the histopathological determining of the lesion type at endometrial level, the cases were studied using immunohistochemical methods, namely by the use of an antibody panel. The immunohistochemical staining of p14 was moderately expressed in the endometrioid carcinoma neuroendocrine cancer day 2020 negative in EH without atypia at nuclear level, and at cytoplasm level, it generally had a positive expression.
In our study, the nuclear and cytoplasmic study of immunoxpression p53, both in hyperplastic lesions and in the endometroid endometrial carcinoma, was negative, similar to the immunohistochemical expression of PTEN. At nuclear level, the immunohistochemical staining of Ki67 was positive in EH with zodia cancerului mihail sadoveanu text and in endometrioid endometrial carcinoma, while at cytoplasm level, it was positive only in endometrioid endometrial carcinoma.
Several publications in the late years report a more frequent and distinctive entity from ARF following beta-hemolytic group A streptococcus infection in patients with post-infectious arthritis, that do not fulfill the modified Jones criteria, the so-called post-streptococcal reactive arthritis PSRA.
A distinctive pattern of clinical framing and biological profile in patients with PSRA following streptococcal tonsillitis is described, with a non-migratory, additive, recent onset days arthritis that affects small and large joints as well, with a bimodal peak of incidence at and years of age, with variate response to non-steroidal anti-inflammatory drugs and has a tendency for recurrence and persistence.
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The main objective of the current study was to evaluate various immunohistochemical patterns of streptococcal tonsillitis in patients with PSRA and find possible correlations with the clinical, biological and ultrasound profile. The studies performed in the last 30 years showed that this bacterium is the main cause of chronic gastritis and the main etiological agent of peptic ulcer and gastric cancer. We investigated the prevalence of HP infection in a group of patients who addressed a gastroenterology medical center betweenin Craiova, Romania, for dyspeptic symptoms.
The patients underwent a clinical, endoscopic and serologic investigation for highlighting a possible HP infection. The age of the patients with neuroendocrine cancer day 2020 duodenal pathology varied between 16 and 87 years old. Of the patients, a number of The study on the distribution of gastric duodenal pathology and HP infection showed that the lesions of the upper digestive tract and HP infection emerged quite early, a number of 29 patients being aged less than 20 years old; among neuroendocrine cancer day 2020, 21 In the age group of years old there were recorded patients, of which There may be observed that in the age group of years old, both the patients with gastric duodenal pathology and the ones with HP infection increased six times in comparison to the first decade.
Most cases were recorded in the patients aged between 50 and 69 years old. The two decades comprised a total number of By evaluating the distribution of HP infection according to the social environment, neuroendocrine cancer day 2020 was observed that there were no significant differences between the patients coming from the urban area and the ones from the rural area, as far as the HP infection was concerned.
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Could oral cytomorphometry be of value in distinguishing diabetes mellitus? Stefan-Claudiu Mirescu, Carmen Georgiu, Anne-Marie Constantin, Adina Bianca Bosca, Camelia-Sidonia Lazar, Alina Simona Sovrea The present study refers to a quantitative, morphometric analysis of exfoliative cytology smears collected from diabetes mellitus DM patients, in order to distinguish subtle changes in cellular and nuclear parameters.
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The study was carried out on 30 adult subjects: a control group of 10 healthy subjects and a study group of 20 diabetic subjects type 1 and type 2 DM. Another factor that was taken into consideration was the abundance of the microbial flora. We found neuroendocrine cancer day 2020 that the cells collected from DM patients had higher values of the nuclear parameters the nuclei were larger and lower neuroendocrine cancer day 2020 dimensions. The nuclear to cytoplasmic ratio was increased in these patients, but the nuclear roundness factor was closer to one in the study group.
Also, an increased number of bacteria, often seen in DM patients, decreased the neuroendocrine cancer day 2020 parameters. Our findings complete recently descriptive cytology studies with the morphological measurements in case of bacterial abundance and sustain the possible value as screening method for morphometry. PDF The relationship between glomerular function and podocyte structure of pre-proteinuria and acute nephrosis in puromycin aminonucleoside-induced rat models: a comparative electron microscopic study Ismail Seckin, Mumin Uzunalan, Meltem Pekpak, Sibel Kokturk, Huseyin Avni Sonmez, Zeynep Banu Gungor, Ozgur Dogus Demirkiran, Halil Ibrahim Saygi, Elif Yaprak Sarac Puromycin aminonucleoside PA has been generally utilized as model of podocyte injury followed by massive proteinuria, severe damage on endocytotic activity of epithelial cells and postmodification of endocytosed compounds.
We aimed to study glomerular function, foot process degeneration and transport pathways of podocytes in pre-proteinuria and acute PAN rats. PA was injected into pre-proteinuria group for three times and acute group for nine times. Proteinuria levels in urine, creatinine and albumin levels in blood were detected 24 hours after PA injections. Renal cortex samples were prepared for transmission electron microscopy. Proteinuria levels in acute group significantly elevated, whereas creatinine clearance, serum albumin levels and urine volumes diminished compared to control and pre-proteinuria groups.
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- Institute of Oncology Prof. Dr. Alexandru Trestioreanu, Romania
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In pre-proteinuria group, hypertrophy and structurally neuroendocrine cancer day 2020 cytoplasm were detected only within podocytes. Acute group had various protein absorption granules secreted from podocyte cytoplasm to the urinary space through exocytosis after lysosomal digestion; but not observed in pre-proteinuria group.
The number of slit pores in pre-proteinuria group decreased, particularly related to fusion of foot processes, subsequently leading to proteinuria. We concluded that foot process fusion begins prior to development of proteinuria although their serum albumin and creatinine clearance levels do not differ significantly.
Additionally, we suggested that in acute PAN, first affected glomerular cells could be podocytes and there could be a correlation between glomerular function and number of slit pores.
A number of six cases of prosthetic knee joint assembly, depending on the malalignment angle, are developed. Stress maps and the values of the maximum von Mises stress on the three prosthesis components: polyethylene insert, tibial component and femoral component, for all studied prosthetic knee assemblies were obtained.
The results show that as the malalignment angle increases, the values of von Mises stresses increase in all prosthesis components. The parameterized virtual models of the knee prosthesis components allow different changes in shape or dimensions, which can lead to the optimization of the implant and to the improvement of the prosthetic knee biomechanics. The aim of the current study is to evaluate the prognostic role of several immunohistochemical IHC markers involved cancer de tip 3 the pathological process of DLBCL.
A significant level of association was observed between high prognostic index values and Bcl-2, Ki67, c-MYC and p53 positive cases.