The endometrial regeneration frontiers: from mechanisms to applications in regenerative medicine Cornelia Amalinei, Ioana Pavaleanu, Adriana Grigoras, Irina-Draga Caruntu, Simona Eliza Giusca, Elena Roxana Avadanei, Ludmila Lozneanu, Raluca Anca Balan The endometrium is a unique and remarkable tissue characterized by a constant regeneration activity and this has been speculative for scientists, regarding its mechanism, regulatory factors, and their significance for fertility and endometrial pathology.
Relatively recent scientific progresses due to genomics, proteomics, and transcriptomics have changed the knowledge in respect with endometrial regeneration and uterine-derived diseases.
Our review is designed to highlight the recent progresses in understanding the endometrial physiology and its alterations involvement in uterine-derived diseases, addressing the current paradigm regarding endometrial regeneration, based on endometrial regenerative cells.
In an attempt to explain the endometrial cancer fertility preservation process of endometrial regeneration, different mechanisms have been proposed during time, from proliferation of basal glandular cells, to mesenchymal-epithelial transition, and lately to differentiation of stromal cells, based on endometrial regenerative cells or stem cells. Their unlimited potential of reconstruction of any type of tissue has been demonstrated and is currently in different trial stages in cell-based therapies of regenerative medicine, opening promising perspectives in severe or lethal diseases, by exploitation of stem cells.
Currently, beside uterine acquired diseases and infertility, endometrial stem cells have been tested in a large spectrum of clinical applications. The great potential of endometrial cells for cell therapies arise from their accessibility, completely xeno-free derivation, allogenic use, possibility of large-scale therapeutic doses production, safety, reproducibility, and chance to overcome the drawbacks associated with autologous therapies.
In order to overcome hostile environment of an injured tissue, the association of endometrial stem cells with other cells or added medium opens the perspective of specific combination available as standardized therapeutic means in the next future.
Oncolog-Hematolog Nr. Keywords oncofertility, cryopreservation, survival, fertilization Rezumat Oncofertilitatea este o nouă ramură a medicinei, dezvoltată din nevoia de a trata cel mai frecvent efect secundar pe termen lung al tratamentului oncologic — infertilitatea.
Emerging concepts and latest advances regarding the etiopathogenesis, morphology and immunophenotype of basal cell carcinoma Mariana Costache, Tiberiu Augustin Georgescu, Ana Maria Oproiu, Diana Costache, Alexandru Naie, Maria Sajin, Adriana Elena Nica Basal cell carcinoma BCC represents the most common skin malignancy, which has been linked over time to multifactorial causes. It usually occurs on sun-exposed areas in people with fair skin and with predilection for men.
Recognizing the symptoms of endometrial cancer
BCC usually affects elderly patients and has endometrial cancer fertility preservation extremely wide range of histological subtypes, which can present clinically under different variants, some with really challenging differentials. In this review, we discuss in detail the latest scientific concepts regarding BCC, its etiology, pathogenesis, genetic bases of disease, morphology and immunophenotype, as well as the currently known genetic syndromes, which may lead to development of multiple BCCs, endometrial cancer cum se elimină papiloamele și condiloamele preservation in young adults.
Zygosity and chorionicity are the key elements in the multiple pregnancy but the placentation issue should be correlated primarily with zygosity, unlike chorionicity that should be correlated with the outcome and complications of multifetal gestation.
Multiple pregnancy is by itself a special maternal-fetal condition, and the monochorionic one, moreover, due to specific complications. These aspects make early assessment of chorionicity and amnionicity a priority. Ultrasound is essential in pregnancy but pathological placental examination after delivery is complementary, in order to have a complete overview of potential mechanisms and pathogenesis affecting twin gestation.
In this review, we highlight both ultrasound aspects specific to multifetal placentation, complemented by macro and microscopic morphological aspects, which underpin the obstetric imaging. Due to these effects, it actively contributes in regulating the normal and pathological angiogenic processes.
Endothelial cells also express co-receptors, such as neuropilin-1 NP-1 and neuropilin-2 NP-2which modulate tyrosine kinase receptor activity. This article aims to highlight the most recent data referring to the VEGF family and its receptors, as well as its implications in the angiogenesis process.
Corresponding author: Carina Mihu, Medical Student; e-mail: carina. In vivo imaging of complicated atherosclerotic plaque - role of optical coherence tomography OCT Mihail Spinu, Dan Mircea Olinic, Maria Olinic, Calin Homorodean Cardiovascular diseases are the main cause of death worldwide, with coronary artery disease CAD being the predominant underlying etiology.
Coronary angiography CA is the current invasive method used for CAD diagnosis, as well as for defining the coronary interventional treatment strategy. However, CA offers sometimes-poor endometrial cancer fertility preservation in estimating atherosclerotic plaque volume, morphology and degree of stenosis severity.
Endometrial cancer ovarian preservation. Profilul de risc clinic asociat cancerului ovarian Conținutul It presents up-to-date information concerning fertility preservation and restoration for patients with hereditary cancer syndromes, disorders of sex development, hematologic diseases, genetic disorders of gonadal dysfunction, immunologic diseases, gynecologic diseases, endocrine endometrial cancer ovarian preservation, and autoimmune and inflammatory diseases. Complex medical conditions are inherently difficult to manage, and reproductive interventions are often not part of the conversation. This book, together with Oncofertility: Fertility Preservation for Cancer Survivors; Oncofertility: Ethical, Legal, Social, and Medical Perspectives; Oncofertility Medical Practice: Clinical Issues and Endometrial cancer ovarian preservation Oncofertility Communication: Sharing Information and Building Relationships across Disciplines; and Pediatric and Adolescent Oncofertility: Best Practices and Emerging Technologies, provides scientific and medically relevant information on fertility preservation from all vantage points and is an indispensable series for those interested in fertility management in cancer or complex settings.
Optical coherence tomography OCT is an intracoronary imaging technique, developed in order to overcome CA limitations and is considered to be an optical biopsy that provides in vivo imaging. OCT has an extremely high resolution, similar to that of a usual histological evaluation of a biopsy sample. One of the most important clinical research areas for OCT is represented by the study of the pathophysiology of coronary and carotid atherosclerotic disease, in order to improve diagnosis and optimize therapy.
This article reviews OCT basic technical aspects related to its diagnosis efficacy, OCT morphological information offered in coronary artery disease, including acute coronary syndromes and non-atherosclerotic coronary disease, OCT use for morphological percutaneous coronary intervention PCI follow-up and stent-failure endometrial cancer fertility preservation, as well as the new three-dimensional 3D -OCT approach for atherosclerotic plaque assessment.
The study analyzed the immunoexpression of epidermal growth factor receptors Endometrial cancer fertility preservation in 53 cases of nodular, adenoid and morpheaform BCCs in relation to clinico-pathological associated parameters. The nodular type presented the weakest expression of EGFRs, while the morpheaform type had a high expression of all receptors and the adenoid type an increased expression only in case of EGFR and HER2. The immune status of microglia is directly correlated to their morphology.
Therefore, microglia morphology is used to distinguish between active and surveilling microglia. After obtaining, in vivo and fixed tissue, single cells images, we manually tracked individually branch segments of normal microglia. The total number of branches and their overall length were analyzed.
Additionally, the number and mean length of each branch order were measured. The overall microglia branching morphology was not different between the two acquisition methods. Furthermore, in our opinion, due to their highly dynamic endometrial cancer fertility preservation, microglia should be detectarea paraziților infecțioși labeled as resting or active, taking also into consideration the imaging method used to obtain the data.
Oncofertilitatea — o şansă la o viaţă normală pentru tinerele supravieţuitoare ale cancerului Endometrial cancer fertility preservation.
Craniofacial morphology and its relation to the eruption pattern of permanent teeth in the supporting zone of the dentition in a group of Romanian children in Timisoara Ancuta Mioara Banu, Denis Mihai Serban, Marius Octavian Pricop, Horatiu Constantin Urechescu, Ciprian Ioan Roi, Costela Lacrimioara Serban The purpose of this study is to determine the endometrial cancer fertility preservation and facial morphological typology in prepubertal children from Timisoara Romania and to develop a population-specific reference for cârlig de vierme dental eruption of permanent teeth in the supporting zone of the dentition, in relation to the facial morphological typology.
Using cephalic and facial indexes in a group of preadolescents with mixed dentition, we endometrial cancer fertility preservation morphological associations between cephalic and facial types, using a cross-sectional design. The prepubertal children in Timisoara have a dominant mesoprosopic facial type and mesocephalic type.
For supporting zone of the dentition, the presence of permanent teeth, the canine, the first premolar and the second premolar was recorded, for all four quadrants. Dental eruption in the supporting zone of the dentition has particularities depending on population group, gender, dental arch, but also facial type.
The leptoprosopic endometrial cancer fertility preservation euryprosopic facial types have a delayed and accelerated eruption compared to the mesoprosopic facial type. The euryprosopic facial type has more intense mandibular eruption. The leptoprosopic facial type registers the largest percentage of children requiring orthodontic treatment.
Markerii tumorali – Tot ce trebuie să ştii
Monitoring the sequence of eruption of the permanent teeth is very important to ensure the balanced development of the dental occlusion, mandible and facies as a whole. Scientists keep improving features of endodontic files in order to obtain anatomically shaped and cleaned root canals and avoid canal transportation, for a better outcome of the endodontic treatment. For the current study, the aim was to evaluate and assess the changes in root canal morphology after instrumentation with PTN and OSNG by using micro-computed tomography CT.
This high-tech resolution tomography allows a much more detailed analysis of the root canal anatomy and its transformation after rotary instrumentation.
We have selected 10 mandibular molars; before and after canal preparation, the samples were distributed in two homogeneous groups PTN and OSNG groups and submitted to standardized radiographs and micro-CT SkyScan, Kontich, Belgium. From the three-dimensional 3D images obtained from the scanning, we were able to perform a two-dimensional 2D perimeter, area and roundnessrespectively a 3D volume, surface area, structure model index analysis, before and after root canal instrumentation.
Results did not revealed important statistical differences among the two groups in relation to the curvature and volume of the root canals before instrumentation; after rotary instrumentation, there was a substantially increase of volume and surface area for all the samples p Corresponding author: Mihail-Claudius Berechet, Teaching Assistant, MD, PhD; e-mail: berechet. Optical biopsy strategy for the assessment of atrophic gastritis, intestinal metaplasia, and dysplasia Silvia Cosmina Drasovean, Alina Mioara Boeriu, Peter Selase Akabah, Simona Liliana Mocan, Ofelia Daniela Pascarenco, Ecaterina Endometrial cancer fertility preservation Dobru Background and aims: The pathogenesis of gastric cancer involves premalignant changes of the gastric mucosa.
An accurate estimation of the topography and severity of these lesions represents an important step in detecting premalignant lesions, thereby classifying endometrial cancer fertility preservation into low or high risk of developing gastric cancer. We prospectively analyzed the diagnostic performance of narrow-band imaging with magnification endoscopy NBI-ME for assessing premalignant gastric lesions during real-time examination.
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- Oncofertilitatea – o şansă la o viaţă normală pentru tinerele supravieţuitoare ale cancerului
Patients, Materials and Methods: A total number of 59 patients were examined by NBI-ME and target biopsies of the antrum, corporeal, and incisura angularis levels. The endoscopic diagnosis was compared to histological findings the gold standard.
The NBI-ME results were assessed for accuracy, sensitivity, specificity, and negative and positive predictive values in detecting intestinal metaplasia, atrophic gastritis and dysplasia. Anatomical considerations on the masseteric fascia and superficial muscular aponeurotic system Delia Hinganu, Cristinel Ionel Stan, Corina Ciupilan, Marius Valeriu Hinganu The masseteric region is considered by the most researchers as a subdivision of the parotideomasseteric region.
Because of its surgical significance, we emphasize it has distinctive morphofunctional features. The aim of this manuscript is to highlight particular characteristics of the masseteric region and practical applications of this concept.
The material used was represented by 12 embalmed cephalic extremities dissected in Ion Iancu Institute of Anatomy, Grigore T. Our results underline the importance and individual arrangement of the superficial muscular aponeurotic system SMAS of the face, at the level of masseteric region. The superficial fascia facilitates adhesion to the dermis of the mimic muscles of the region.
This reveals that the masseteric superficial fascia will follow the masticatory movements of the mandible and masseter, but also those of the minor and major zygomaticus muscles.
These muscles are the infra-SMAS layer and thus take part in endometrial cancer fertility preservation formation of a unitary complex together with the superficial fascia.
The particularities of the SMAS in the masseteric region are especially important in plastic and reconstructive surgery.
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
The two-dimensional 2D sheets were obtained by electrospinning technique, with giardia u psow leczenie aim to produce multifunctional wound dressing with regenerative and even anti-infective roles. The most important advantages of the electrospinning technique are related to the possibility of obtaining fibers with controlled morphology, usually having high specific surface and water and air penetration and the possibility of functionalizing these fibers and nets depending on the desired application.
These advantages make it possible to use electrospinning for a wide range of biomedical applications, such as tissue engineering, controlled release, implantology, wound healing, and more. The obtained composite materials were characterized by infrared IR spectroscopy and scanning electron microscopy SEM and tested against common pathogens: Pseudomonas aeruginosa Gram-negative stainingStaphylococcus aureus Gram-positive staining and Candida albicans fungus.
Clinical and morphological correlations in early diagnosis of endometrial cancer Adrian Dilde papilloma tedavisi, Madalina Lucia Marcu, Catalina Diana Stanica, Anca Daniela Braila, Irina Pacu, Raluca Gabriela Ioan, Cicerone Catalin Grigorescu, Cringu Antoniu Ionescu The prevalence of endometrial cancer among asymptomatic women is rather reduced also due to the absence of a cost-efficient test, as there are no ideal screening examinations for endometrial cancer.
Several methods were proposed in medical practice to discover endometrial neoplasia at an early stage, among which: endometrial biopsy, endovaginal ultrasound, targeted biopsy hysteroscopy. This study was made on a group of 38 patients monitored for metrorrhagia in the interval between July 1, July 1, All patients were monitored clinically and by ultrasound, endometrium samples were taken by biopsied uterine curettage, and a histopathological examination was performed, completed by immunomarking, whenever necessary.
The clinical and paraclinical methods ce pastile poti bea din paraziti for the creation of a protocol by which patients were monitored. This protocol allowed for the modulation and effectiveness of the treatment, establishing the best therapeutic conduct and the remote supervision.
This type of tumors is usually asymptomatic until they reach a large size. They can be solitary or multiple. When multiple and symmetrical distributed around neck area, the lesions can be classified as Madelung s disease, a rare condition that affects mostly Mediterranean men. Our objective was to describe the symptoms, cytological and histological aspects, diagnostic problems and treatment strategies of the large size lipomas and to highlights that the differential diagnosis between common lipoma of cervical endometrial cancer fertility preservation and Madelung s disease can be established only on clinical grounds, with major implications in endometrial cancer fertility preservation treatment options.
Materials and Methods: The study was retrospective and analyzed archived material. We selected four cases of cervical lipomas, each with its particularities, treated in the Clinic of Oral and Maxillofacial Surgery, Timisoara City Hospital, Romania. For all the cases, we performed a fine-needle aspiration with consequent cytological exam.
The microscopic evaluation of Papanicolaou-stained slides established the diagnosis of lipomas. The surgically removed specimens were sent to the Department of Pathology.
The excised specimens were prepared with routine histological technique. Results: The cases presented one or more lateral cervical swelling of the neck, inserted among major endometrial cancer fertility preservation elements, becoming life-threatening conditions. All the endometrial cancer fertility preservation studied had the same cytological and histopathological features consistent with lipoma, fibrolipoma or angiolipoma, but, instead of this, clinical aspects differed from case to case.
On clinical grounds, two patients were considered as Madelung s diseases. Conclusions: Despite of the same histopathological aspects, lateral cervical lipomas can be classified in varies categories with different treatment strategies and prognostic factors.
The correct diagnosis of Madelung s disease is important in order to add other treatment options to the surgery or liposuction as avoiding alcohol or medication for metabolic disorders. The upper endoscopy was negative, but the barium meal discovered an apparently extrinsic duodenal D3 stenosis; abdominal ultrasound diagnosed a left liver mass suggesting a metastatic tumor.
The hematochezia relapse, with hemodynamic instability imposed emergency surgery; on laparotomy, a bleeding tumor located endometrial cancer fertility preservation the duodenopancreatic region was discovered, and a pylorus-preserving pancreaticoduodenectomy Traverso-Longmire was performed.
The postoperative evolution was favorable, the patient being alive, four years after the surgery.
It is usually encountered in patients already suffering from a long-established liver disease that has evolved past the stage of liver cirrhosis. It is usually associated with viral liver infections, alcohol consumption or other dietary habits that lead to liver damage. Metastases are not rare and are usually found incidentally after a period of monitoring the main liver disease. We present here a rare case of HCC metastasis endometrial cancer fertility preservation in the right gluteal region, in a hepatitis C virus-infected patient also displaying lung tumor lesions.
Diagnosis of both the metastasis and of the primary tumor were found during the same hospital visit, employing contrast-enhanced computed tomography, magnetic resonance imaging and ultrasound USwith positive biopsy of the metastatic lesion, performed under US guidance. The patient received oncological treatment, with good prognosis and stable evolution during the next eight months since diagnosis. According to previous studies, the size and location endometrial cancer fertility preservation the tumor are correlated with the appearance of symptoms and complications.
Cases of hemangiomas complicated by spontaneous intratumoral hemorrhage have been rarely reported in the literature. Here, we report the case of a year-old woman admitted for persistent upper abdominal pain. The patient showed signs of anemia, inflammatory markers and a transient increase in creatinine levels, which were corrected by conservative treatment.
Our patient denied the previous use of estrogen derivatives, smoking or alcohol consumption.
Native computed tomography identified a liver mass measuring 73x63 mm, located in segment IV and bulging out of the anterior contour of the liver. The mass was surgically removed by hepatic segmentectomy, and histopathological examination identified a cavernous hemangioma complicated by intratumoral hemorrhage.
The postoperative outcome was wart treatment usa. After a literature review, we identified 19 other cases of hepatic cavernous hemangioma complicated by intratumoral hemorrhage reported worldwide.
Vanek s tumor: a rare cause of gastric outlet obstruction. We present an unusual case of a year-old female patient, investigated for intermittent nausea, vomiting, abdominal pain and anemia. Narrow-band imaging NBI endoscopy showed a polypoid tumor with normal coverage mucosa prolapsing through the pylorus. Endometrial cancer fertility preservation tumor was surgically removed.
Histopathological HP examination revealed the presence of spindle cells with uniform nuclei exhibiting no mitotic activity. The inflammatory cells were predominantly represented by eosinophils. The vascular component was prominent suggesting a vascular lesion.
We put emphasis on the presentation of this particular case because of its scarcity among the other types of gastric polyps, suspicion for features of malignancy, and the endometrial cancer fertility preservation of the clinical presentation, consisting of intermittent gastric outlet obstruction ball valve syndrome accompanied by weight loss endometrial cancer fertility preservation anemia.
The differential diagnosis of other benign or malignant gastric lesions was based on endoscopic, computed tomography and HP aspects. Case report and literature review PDF Most synovial sarcomas are found at the extremities, especially in the lower limbs. Pius Brinzeu Clinical Hospital, Timisoara, Romania, for evaluation of a mass located in the anterior region of the elbow.
Imagistic, histological and immunohistochemically evaluations established the diagnosis of monophasic spindle cell SS G2. Block excision of the tumor with oncological safety margins was performed followed by total elbow arthroplasty. The patient then received radio- and chemotherapy. The case was followed-up at regular intervals for local recurrence and metastases and was free of symptoms at two years. Early diagnosis of SS, multimodal therapies and performing an arthroplasty of the elbow allowed the patient to resume daily activities.
The unpredictable evolution requires regular follow-up for a long period of time. We present the case of a year-old patient diagnosed with Epstein syndrome and hyperparathyroidism secondary to chronic kidney disease.