Cancer cap chemo
Disciplina Oncologie, Facultatea de Medicină, U. Chimioterapia de inductie urmata de radiochimioterapie este standardul terapeutic in cancerele capului si gitului avansate locoregional.
Aditia Cetuximab la iradiere determina o imbunatatire semnificativa a controlului locoregional si a supravietuirii.
Radiochimioterapia concomitenta cu Cetuximab ramine o alternativa eficienta pentru pacientii, care nu pot primii Cisplatin. Studiile viitoare urmaresc decelarea altor agenti terapeutici administrati concomitent cu radiochimioterapia concomitenta cu Cetuximab.
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Supravietuirea mediana a fost imbunatatita cu 2,7 luni de la 7,4 la 10,1 luni. CUVINTE CHEIE Cancer cap si git, markeri moleculari, prognostic, tratament Modern trends in the management of advanced locoregional head and neck cancer ABSTRACT The rationale for molecular detection in HNSC is improved screening and diagnosis detected hypermethylated TSG promoters in pretreatment saliva from HNSC patients which can to be a surveillance model and prediction of recurrence cancer cap chemo application to sceening populationimproved treatment target molecular terapie and improved posttreatment monitoring the surveillance of patients with mutant gene p53 is statistical smaller cancer cap chemo the delta Np63 variant of p53 is correlated with Cisplatin sensitivity.
The consequenthy induction chemotherapy followed by chemoradiotherapy is standard therapy in head and neck cancer. Addition of Cetuximab to radiotherapy improved locoregional control and survival.
Studies ongoing to develop regimens incorporating Cetuximab with chemoradiotherapy. Median overall survival was prolonged by 2,7 months with addition Cetuximab of chemotherapy arm compared to chemotherapy alone arm 7,4 to 10,1 months Addition of Cetuximab did not modify the characteristic adverse event profile of platinum-based chemotherapy.
